Pet Medication 101: Ketoconazole

1. Drug Name:

ketoconazole

2. Brand Names:

Nizoral, Ketochlor

3. How Dispensed:

Prescription only

4. Forms:

200mg tablets, topical cream, shampoo (with Chlorhexidine)

5. Drug Type/Class:

Antifungal

6. Uses in Cats and Dogs:

Treats fungus of the lymph nodes, skin, nails, respiratory system, bone, and other parts of the body

7. How it Works:

Ketoconazole works by inhibiting the production of a fungal cell wall. This causes the fungus to be structurally deficient, making it unable to reproduce or survive.

8. Side Effects and/or Signs of Overdose:

• Loss of appetite

• Vomiting

• Diarrhea

• Weight loss

• Dizziness

• Light sensitivity

• Liver toxicity/jaundice

• Cortisol suppression

• Low platelets

• Bleeding of the mouth

• Haircoat color change

• Cataracts

9. Drug Interactions:

• Alprazolam

• Aminophylline/Theophylline

• Amlodipine

• Antacids

• Astemizole

• Buspirone

• Busulfan

• Ciprofloxacin

• Cisapride

• Cyclosporine

• Diazepam

• Digoxin

• Doxorubicin

• Fentanyl

• H2 blockers

• Methylprednisolone

• Midazolam

• Mitotane

• Phenytoin sodium

• Rifampin

• Sildenafil

• Sucralfate

• Tramadol

• Triazolam

• Vincristine/Vinblastine

• Warfarin sodium

10. Cautionary Statements:

• Due to its toxic side effects and the availability of safer options, use in cats is generally not recommended.

• Use with caution in patients with liver disease, low platelet counts, and those undergoing surgical procedures.

• Use with caution in patients with serious illnesses or trauma.

• Do not use in pregnant pets unless it is for a life-threatening infection.

• Use with caution in breeding pets, as it can cause temporary infertility.

• Use with caution in nursing pets because it is excreted in the milk.

Read more:

Ringworm in Cats and Dogs

Aspergillosis in Dogs and Cats

Medication Info Sheet: Fluconazole

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