amitriptyline hydrochloride
Elavil, Endep, Entrip
Prescription only
10 mg, 15 mg, 25 mg, 50 mg, 75 mg, 100 mg, 150 mg amitriptyline hydrochloride film-coated tablets
Oral dose combination products containing chlordiazepoxide or perphenazine
Tricyclic antidepressant, adrenergic uptake inhibitor, nonnarcotic analgesic
Used in dogs, cats, and birds for treatment of certain behavioral disorders such as generalized or separation anxiety and spraying. Used for treatment of neuropathic pain in dogs and cats.
Amitriptyline blocks reuptake (absorption) of the hormones norepinephrine and serotonin. This allows these hormones to be at a higher level to stabilize mood and increase feelings of well-being.
Side effects include sedation, and rarely constipation and urinary retention. Occasionally dogs may become hyperexcitable and rarely develop seizures from amitriptyline. Cats may salivate excessively and have decreased appetite.
Signs of overdose include vomiting, diarrhea, restlessness, agitation, vocalization, seizures, loss of consciousness, increase in heart rate, muscle tremors, fasciculations, and can even lead to death.
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