Pet Medication 101: AmitriptylineIt’s important to understand a medication’s uses and side effects before giving it to your pet. This medication info sheet is meant to give you a good understanding of what Amitriptyline is used for, how it works, and potential side effects in cats and dogs. Always consult a veterinarian before giving your pet any medication. Are you concerned about your pet?Book a video consultation with an experienced veterinarian within minutes.Professional vet advice onlineLow-cost video vet consultationsOpen 24 hours a day, 365 days a year Book Video Consultation 1. Drug Name:amitriptyline hydrochloride2. Brand Names:Elavil, Endep, Entrip3. How Dispensed:Prescription only4. Forms:10 mg, 15 mg, 25 mg, 50 mg, 75 mg, 100 mg, 150 mg amitriptyline hydrochloride film-coated tabletsOral dose combination products containing chlordiazepoxide or perphenazine5. Drug Type/Class:Tricyclic antidepressant, adrenergic uptake inhibitor, nonnarcotic analgesic6. Uses in Dogs and Cats:Used in dogs, cats, and birds for treatment of certain behavioral disorders such as generalized or separation anxiety and spraying. Used for treatment of neuropathic pain in dogs and cats.7. How it Works:Amitriptyline blocks reuptake (absorption) of the hormones norepinephrine and serotonin. This allows these hormones to be at a higher level to stabilize mood and increase feelings of well-being.8. Side Effects and/or Signs of Overdose:Side effects include sedation, and rarely constipation and urinary retention. Occasionally dogs may become hyperexcitable and rarely develop seizures from amitriptyline. Cats may salivate excessively and have decreased appetite.Signs of overdose include vomiting, diarrhea, restlessness, agitation, vocalization, seizures, loss of consciousness, increase in heart rate, muscle tremors, fasciculations, and can even lead to death.9. Drug Interactions:Selective-serotonin reuptake inhibitors (fluoxetine)Thyroid medicationsClonidineCimetidineEphedrineMephentermineCisaprideDiazepamMonoamine oxidase inhibitors (selegiline, amitraz)Quinidine10. Cautionary Statements:Amitriptyline should not be administered to pets with any of the following conditions:Hyperthyroidismseizure disorderscardiac dysrhythmia narrow-angle glaucomapatients taking thyroid medicationPatients experiencing problems with urinary retention or urine flow, which may include those with prostatic hypertrophy, should avoid the use of amitriptyline.Should not be used within two weeks of administering monoamine oxidase inhibitors (MAOIs) such as amitraz or selegiline.It may take several weeks to see clinical effects and behavioral improvement.Read more:Tips for Helping Your Dog with Separation AnxietySeparation Anxiety in CatsFeather Picking and Self-Mutilating BehaviorsNeed to speak with a veterinarian regarding your pet's medication or another condition?Click here to schedule a video consult to speak to one of our vets. You can also download the FirstVet app from the Apple App Store and Google Play Stores.