Pet Medication 101: Onsior
It’s important to understand a medication’s uses and side effects before giving it to your pet. This medication info sheet is meant to give you a good understanding of what Onsior (robenaxocib) is used for, how it works, and potential side effects in cats and dogs. Always consult a veterinarian before giving your pet any medication.
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1. Drug Name:
2. Brand Name:
3. How Dispensed:
5mg, 6mg, 10mg, 20mg, 40 mg tablets
20mg/mL injectable solution
5. Drug Type/Class:
Non-steroidal anti-inflammatory drug (NSAID)
6. Uses in Dogs and Cats:
7. How it Works:
Robenacoxib blocks the enzyme (protein that increases the rate of a chemical reaction) cyclooxygenase (COX-2). Blocking this enzyme decreases the production of prostaglandins that causes the pain and swelling of inflammation and other conditions. Inhibiting COX-2 provides anti-inflammatory, pain relief, and can decrease fever.
8. Side Effects and/or Signs of Overdose:
Gastrointestinal side effects are common and can occur in 10% of dogs and cats. These side effects include vomiting, soft stool to diarrhea, decreased appetite, and blood in the stool. Some pets may have a decrease in energy levels. Elevated liver enzymes are common in dogs on long-term robenacoxib.
Overdosage can cause gastrointestinal upset and adverse effects on the kidney. Gastrointestinal ulceration can occur which can cause perforation (development of a hole) in the stomach or intestine. This can lead to infection and inflammation in the abdomen (peritonitis) or throughout the entire body (sepsis).
9. Drug Interactions:
- Corticosteroids and other NSAIDs increase the risk of gastrointestinal toxicity
- Aminoglycoside antibiotics (such as gentamicin or amikacin) may increase the risk of kidney toxicity
- Insulin may increase the risk of hypoglycemia
- Aspirin and clopidogrel increase the risk of bleeding
10. Cautionary Statements:
- NSAIDs should only be used in animals that are otherwise healthy. Do not use in patients who are dehydrated or have impaired heart or kidney function
- Animals should be closely monitored, and clients should be advised of the clinical signs of, side effects of NSAIDs
- Risk factors for side effects include: disease of the liver, gastrointestinal tract, and kidney
- Liver injury may occur with robenacoxib
- Bloodwork is recommended before starting an NSAID and monitoring liver and kidney bloodwork if being used long term
- Contraindicated in pregnant and lactating animals
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