Pet Medication 101: Orbax

1. Drug Name:

Orbifloxacin

2. Brand Names:

Orbax

3. How Dispensed:

Prescription-only

4. Forms:

22.7mg and 68mg tablets

30mg/mL oral suspension

5. Drug Type/Class:

Fluoroquinolone antibiotic

6. Uses in Dogs and Cats:

Orbifloxacin is approved for the treatment of infections caused by susceptible bacteria in dogs and cats.

7. How it Works:

Orbifloxacin blocks two enzymes that interfere with DNA replication, which destroys the bacteria.

8. Side Effects and/or Signs of Overdose:

Gastrointestinal side effects are common and can occur in dogs and cats. These side effects include vomiting, hypersalivation (excessive drooling), and decreased appetite. Some pets may have a decrease in energy levels. Convulsions are another possible side effect seen in both dogs and cats.

Additional side effects are reported in cats only and include blindness, which can be temporary or permanent. Other eye issues include mydriasis (dilated pupils) and ataxia (wobbly gait).

In young dogs that are still growing, fluoroquinolone antibiotics can damage the cartilage of joints.

Overdosage in dogs may cause gastrointestinal issues, vomiting, diarrhea, hypersalivation, and liver issues including inflammation and elevation in liver values. Cat overdosage can result in gastrointestinal signs as well as eye changes.

9. Drug Interactions:

• Cimetidine
• Cyclosporine – may reduce metabolism and increase the risk of toxicity to kidneys
• May increase the action of oral anticoagulants

10. Cautionary Statements:

• Using orbifloxacin should be based on bacterial susceptibility to decrease chances of causing antibiotic resistance
• Cartilage damage can occur in growing animals and this is dose-dependent. Orbifloxacin is contraindicated in dogs who are rapidly growing, which includes small and medium-sized breeds up to 8 months of age, and large and giant breeds up to 18 months of age
• Administer with caution in animals with liver insufficiency, central nervous system disorders, and a history of seizures
• Fluoroquinolones can affect the retina of the cat and should be used with caution, particularly in elderly cats or those with kidney or liver issues
• Avoid in pets with a history of tendon disorders

Read more:

Urinary Tract Infections in Dogs

Pyometra (uterine infection) in Dogs

Skin Infections in Dogs

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