Pet Medication 101: Pepto-BismolIt’s important to understand a medication’s uses and side effects before giving it to your pet. This medication info sheet is meant to give you a good understanding of what Pepto-Bismol (bismuth subsalicylate) is used for, how it works, and potential side effects in cats and dogs. Always consult a veterinarian before giving your pet any medication.FirstVet is the #1 online video veterinary service.FirstVet offers video calls with experienced veterinarians for just $35. You can get a consultation within minutes by downloading the FirstVet app for free from the Apple App Store or Google Play Store. Over 500,000 users trust FirstVet to care for their animals. Rating: 4.9 - more than 1600 reviewsRating: 4.9 - more than 1300 reviewsRating: 4.9 - more than 1600 reviews Download app 1. Drug Name:Bismuth subsalicylate2. Brand Names:Pepto-Bismol, Bismatrol, Bismukote, Bismupaste, Corrective, Gastrocote, Kaopectate, Mismusol3. How Dispensed:Over the counter4. Forms:262mg tablets, 262mg oral chewables, and oral liquid (1050mg/10mL, 527mg/30mL, 525mg/30mL, 525mg/15mL, 262mg/15mL)5. Drug Type/Class:Antidiarrheal6. Uses in Dogs and Cats:Diarrhea, upset stomach, maldigestion, and stomach infections caused by Helicobacter bacteria. Not safe for use in cats.7. How it Works:The exact mechanism of action is not fully understood. The bismuth interacts with acidic components in the stomach to form bismuth salts, which prevent bacteria from binding and growing on the mucosal cells of the stomach.This reduces gastrointestinal inflammation and promotes the healing of pre-existing stomach ulcers. The salicylate limits the formation of prostaglandin, which is a hormone-like substance that promotes inflammation and fluid secretion.8. Side Effects and/or Signs of Overdose:Common side effects include discolored stools (gray-black or green-black) and constipation. Signs of overdose may include weakness, depression, anxiety, problems with balance, confusion, or tremors.9. Drug Interactions:Aspirin, ACE inhibitors, loop diuretics, NSAIDs, and Tetracycline10. Cautionary Statements:Never give your pet Pepto-Bismol without the approval of your veterinarian.This drug is not considered safe for use in cats.Use cautiously in pets with bleeding disorders.Use cautiously in pets who are pregnant or nursing.Do not give this medication within 2 hours of other medications.Although Pepto-Bismol side effects usually resolve after 24 hours, side effects may persist longer in patients with liver or kidney disease.Do not use in pets that have stomach or intestinal ulcers.Do not use in pets that are allergic to NSAIDs or aspirin.Use in young or debilitated animals is not recommended as constipation and fecal impaction can occur.May interact with laboratory tests such as urine glucose or ketones.May interfere with radiographs (x-rays).Read more:Medication Info Sheet: KaopectateVomiting and Diarrhea in DogsVomiting and Diarrhea in CatsNeed to speak with a veterinarian regarding your dogs medication or another condition?Click here to schedule a video consult to speak to one of our vets. You can also download the FirstVet app from the Apple App Store and Google Play Stores.