Pet Medication 101: Spironolactone It’s important to understand a medication’s uses and side effects before giving it to your pet. This medication info sheet is meant to give you a good understanding of what spironolactone is used for, how it works, and potential side effects in cats and dogs. Always consult a veterinarian before giving your pet any medication. Are you concerned about your pet?Book a video consultation with an experienced veterinarian within minutes.Professional vet advice onlineLow-cost video vet consultationsOpen 24 hours a day, 365 days a year Book Video Consultation 1. Drug Name:Spironolactone2. Brand Names:Aldactone, Prilactone, Tempora, CaroSpir (oral liquid)3. How Dispensed:Prescription-only4. Forms:Tablets 12.5mg, Tablets 25mg, Tablets 50mg, Tablets 100mg, Oral Suspension 25mg/5ml5. Drug Type/Class:Diuretic, aldosterone receptor antagonist6. Uses in Dogs and Cats:Spironolactone is used as adjunctive therapy in congestive heart failure. It has also been used to treat ascites (fluid accumulation in the abdomen) and hypertension seen with kidney disease.7. How it Works:Spironolactone works on the kidneys, helping turn excess body fluid into urine. It is considered potassium-sparing, preventing your pet’s body from absorbing too much salt. This keeps your pet’s potassium levels from getting too low.8. Side Effects and/or Signs of Overdosage:This medication may cause increased thirst, increased urination, lethargy, mild electrolyte abnormalities, muscle weakness, and heartbeat changes.9. Drug Interactions:The following drugs should be avoided when taking spironolactone: digoxin, mitotane, salicylates, neuromuscular blocking agents, cyclosporine, and other potassium-sparing diuretics10. Cautionary Statements:Spironolactone should be avoided in animals with kidney impairment, liver disease, Addison's disease, or excessive blood potassium levels.Read more:Pet Medication 101: FurosemidePet Medication 101: EnalaprilPet Medication 101: BenazeprilNeed to speak with a veterinarian regarding your pet’s medication or another condition?Click here to schedule a video consult to speak to one of our vets. You can also download the FirstVet app from the Apple App Store and Google Play Stores.