Pet Medication 101: Prozac It’s important to understand a medication’s uses and side effects before giving it to your pet. This medication info sheet is meant to give you a good understanding of what Prozac (fluoxetine) is used for, how it works, and potential side effects in cats and dogs. Always consult a veterinarian before giving your pet any medication. 1. Drug Name: 2. Brand Names: 3. How Dispensed: 4. Forms: 5. Drug Type/Class: 6. Uses in Dogs and Cats: 7. How it Works: 8. Side Effects and/or Signs of Overdose: 9. Drug Interactions: 10. Cautionary Statements: Read more: Need to speak with a veterinarian regarding your pet's medication or another condition? Are you concerned about your pet?Book a video consultation with an experienced veterinarian within minutes.Professional vet advice onlineLow-cost video vet consultationsOpen 24 hours a day, 365 days a year Book Video Consultation 1. Drug Name:fluoxetine hydrochloride2. Brand Names:Reconcile, Prozac, Olena, Prozep, Prozet, Zactin, Lovan, Sarafem, Selfemra3. How Dispensed:Prescription-only4. Forms:Veterinary formulation: 8mg, 16mg, 32mg, 64mg chewable tabletsHuman formulations: 10mg, 20mg, 40mg, 60mg capsules; 90mg delayed-release capsules; 10mg, 15mg, 20mg, 40mg, 60mg oral tablets; 20mg/5mL oral solution25mg and 50mg combination products containing olanzapine5. Drug Type/Class:Selective serotonin reuptake inhibitor (SSRI); behavior modifier6. Uses in Dogs and Cats:Used in dogs for separation anxiety, and in dogs and cats for aggression, generalized anxiety, compulsive behavior, and inappropriate urination.7. How it Works:Fluoxetine increases serotonin activity. Serotonin is a chemical that stabilizes mood, feelings of well-being and happiness, as well as aids in sleeping and digestion.8. Side Effects and/or Signs of Overdose:Side effects include decreased energy levels, decreased appetite, and gastrointestinal signs such as vomiting, diarrhea, and excessive salivation. Incoordination can also occur. Cat owners reported constipation and urinary retention.Signs of overdose include excessive sedation. Very high doses can cause serotonin syndrome, a serious drug reaction that can lead to many adverse effects including diarrhea, high heart rate, high respiratory rate, hypertension, tremors, seizures, abnormally high body temperatures, and even coma or organ failure in the most severe cases.9. Drug Interactions:Coadministration with other SSRIs or drugs that increase serotonin levels increase the risk of serotonin syndromeChlorpheniramineOpiatesTramadolTrazodoneClomipramineAmphetaminesDiazepamMonoamine oxidase inhibitors (selegiline, amitraz)Quinidine10. Cautionary Statements:Fluoxetine should not be used in patients with exposure to other drugs that increase serotonin within 2 weeksIn some rare instances, fluoxetine increases aggressive behavior so should be used with caution when initiating therapy in aggressive patientsFull effects may take 4-8 weeks in some patientsFluoxetine should be tapered over 3-4 weeks and not discontinued abruptly. Gradual withdrawal is recommended to decrease unwanted symptoms such as agitation, anxiety, and confusionAppetite and body weight should be monitored closelyUse with caution in patients with bleeding disorders and kidney diseaseRead more:Separation Anxiety in CatsHow to Find the Right Dog TrainerPuppy Training ToolboxNeed to speak with a veterinarian regarding your pet's medication or another condition?Click here to schedule a video consult to speak to one of our vets. You can also download the FirstVet app from the Apple App Store and Google Play Stores.