1. Drug Name:

Trimeprazine tartrate with prednisolone

2. Brand Names:

Temaril-P, Vanectyl-P

3. How Dispensed:

Prescription-only

4. Forms:

Tablets 5mg trimeprazine combined with 2mg prednisolone

5. Drug Type/Class:

Antihistamine with a steroid

6. Uses in Dogs and Cats:

Temaril-P is used to treat allergies, itchy skin, and coughs in dogs and cats. More specifically, it is used to treat allergic dermatitis, tracheobronchitis, allergic bronchitis, and coughs of non-specific origin.

7. How it Works:

Trimeprazine is an antihistamine that competes with histamine in the bloodstream by attaching itself to histamine receptors. Prednisolone is a steroid that binds to cyclophilin and inhibits calcineurin which inhibits T-cell function.

8. Side Effects and/or Signs of Overdose:

Trimeprazine could cause drowsiness, tremors, or muscle weakness. Prednisolone could increase thirst, increase urination, increase appetite, restlessness, and panting. Other more serious side effects like infection, anorexia, vomiting, diarrhea, pot-bellied appearance, weight gain, and aggression have been reported.

9. Drug Interactions:

Temaril-P should be used with caution with ACE inhibitors, antacids, cyclosporine, digoxin, diuretics, estrogen, insulin, ketoconazole, NSAIDs like Rimadyl, phenobarbital, and rifampin.

10. Cautionary Statements:

Temaril-P should be given with food to help prevent stomach upset. It may cause drowsiness. It should be avoided in pregnant pets and should be used with caution in pets with liver or kidney disease.

Read more:

Diagnosing and Treating Environmental Allergies in Dogs

Causes and Treatment for Coughing in Cats

Canine Infectious Respiratory Disease Complex (CIRDC)

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